Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q6UB35 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Hamster, Monkey, Pig, Horse, Xenopus, Bovine, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 106kDa |
| Dilution | ELISA (1:32000), IHC-P (5 µg/ml), WB (0.1-0.3 µg/ml) |
| Gene ID | 25902 |
|---|---|
| Other Names | Monofunctional C1-tetrahydrofolate synthase, mitochondrial, 6.3.4.3, Formyltetrahydrofolate synthetase, MTHFD1L, FTHFSDC1 |
| Target/Specificity | Human MTHFD1L. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | FTHFSDC1 / MTHFD1L Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MTHFD1L (HGNC:21055) |
|---|---|
| Synonyms | FTHFSDC1 |
| Function | May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2. |
| Cellular Location | Mitochondrion. |
| Tissue Location | Detected in most tissues, highest expression found in placenta, thymus and brain. Low expression is found in liver and skeletal muscle. Up-regulated in colon adenocarcinoma |
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Provided below are standard protocols that you may find useful for product applications.
Background
May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2.
References
Prasannan P.,et al.J. Biol. Chem. 278:43178-43187(2003).
Sugiura T.,et al.Biochem. Biophys. Res. Commun. 315:204-211(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Mungall A.J.,et al.Nature 425:805-811(2003).
Walkup A.S.,et al.Arch. Biochem. Biophys. 442:196-205(2005).
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