GA-017 [2351906-74-4]
Referencia HY-147082-1ml
embalaje : 10mM/1mL
Marca : MedChemExpress
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GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids.
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GA-017 Estructura química
No. CAS : 2351906-74-4
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
| Descripciòn |
GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids[1]. |
IC50 & Target |
IC50: 3.92 ± 0.42 nM (LATS2), 4.10 ± 0.79 nM (LATS1)[1] |
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| In Vitro |
GA-017 suppresses the cell death of HUVECs and promotes their cell growth[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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| Peso molecular |
343.38 |
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| Fòrmula |
C18H21N3O4 |
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| No. CAS |
2351906-74-4 |
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| Appearance |
Solid |
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| Color |
Off-white to light yellow |
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| SMILES |
O=C(NCC1=CC(O)=CC=C1)N/N=C(CC)\C2=CC=C(C(C)=C2O)O |
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| Envío | Room temperature in continental US; may vary elsewhere. |
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| Almacenamiento |
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| Solvente y solubilidad |
In Vitro:
DMSO : 20.83 mg/mL (60.66 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
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| Pureza y Documentación |
Purity: 98.92% |
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| Referencias |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.9122 mL | 14.5611 mL | 29.1223 mL | 72.8056 mL |
| 5 mM | 0.5824 mL | 2.9122 mL | 5.8245 mL | 14.5611 mL | |
| 10 mM | 0.2912 mL | 1.4561 mL | 2.9122 mL | 7.2806 mL | |
| 15 mM | 0.1941 mL | 0.9707 mL | 1.9415 mL | 4.8537 mL | |
| 20 mM | 0.1456 mL | 0.7281 mL | 1.4561 mL | 3.6403 mL | |
| 25 mM | 0.1165 mL | 0.5824 mL | 1.1649 mL | 2.9122 mL | |
| 30 mM | 0.0971 mL | 0.4854 mL | 0.9707 mL | 2.4269 mL | |
| 40 mM | 0.0728 mL | 0.3640 mL | 0.7281 mL | 1.8201 mL | |
| 50 mM | 0.0582 mL | 0.2912 mL | 0.5824 mL | 1.4561 mL | |
| 60 mM | 0.0485 mL | 0.2427 mL | 0.4854 mL | 1.2134 mL |