Glutamate Receptor 1 Positive Control peptide

Formulation:	Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range:	WB: 1:500
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	GRIA1
Gene ID:	2890
Uniprot ID:	GRIA1_HUMAN

Tissue Specificity	Widely expressed in brain.
Post Translational Modifications	Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. Phosphorylated at Ser-645. Phosphorylated at Ser-710 by PKC. Phosphorylated at Ser-849 by PKC, PKA and CAMK2. Phosphorylated at Ser-863 by PKC, PKA and PRKG2. Phosphorylation of Ser-863 is reduced by induction of long-term depression and increased by induction of long-term potentiation.
Function	Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
Peptide Name	Glutamate Receptor 1 Glur-1 Ampa-Selective Glutamate Receptor 1 Glur-A Glur-K1 Glutamate Receptor Ionotropic - Ampa 1 Glua1
Database Links	Reactome: R-HSA-204005 Reactome: R-HSA-399710 Reactome: R-HSA-399719 Reactome: R-HSA-416993 Reactome: R-HSA-438066 Reactome: R-HSA-5694530 Reactome: R-HSA-8849932 Reactome: R-HSA-9620244
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Endoplasmic Reticulum Membrane Postsynaptic Cell Membrane Postsynaptic Density Membrane Cell Projection Dendrite Dendritic Spine Early Endosome Membrane Recycling Endosome Membrane Presynapse Synapse Interaction With Cacng2 Cnih2 And Cnih3 Promotes Cell Surface Expression Colocalizes With Pdlim4 In Early Endosomes Displays A Somatodendritic Localization And Is Excluded From Axons In Neurons Localized To Cone Photoreceptor Pedicles
Alternative Peptide Names	Glutamate Receptor 1 protein Glur-1 protein Ampa-Selective Glutamate Receptor 1 protein Glur-A protein Glur-K1 protein Glutamate Receptor Ionotropic - Ampa 1 protein Glua1 protein GRIA1 protein GLUH1 protein GLUR1 protein

Information sourced from Uniprot.org

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