Human CD11bC Antibody : APC
Referencia OASB02602
embalaje : 25tests
Marca : Aviva Systems Biology
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Human CD11bC Antibody : APC (OASB02602)
| Datasheets/Manuals | Printable datasheet for Human CD11bC Antibody : APC (OASB02602) |
|---|
| Tested Species Reactivity | Human |
|---|---|
| Predicted Species Reactivity | Human |
| Product Format | Liquid. Phosphate buffered saline containing 0.1% sodium azide and a stabilizer |
| Clonality | Monoclonal |
| Host | Mouse |
| Conjugation | APC |
| Application | FC |
| Additional Information | Description: CD11b is the 165 kDa alphaM chain which combines with the CD18 beta2 integrin subunit to form the Mac-1 heterodimer. It is expressed on activated lymphocytes, monocytes, granulocytes and a subset of NK cells. CD11b functions in cell-cell and cell-substrate interactions and is a ligand for C3bi, CD50 (ICAM-3), CD54 (ICAM-1) and CD102 (ICAM-2). |
| Reconstitution and Storage | Store at 2-8C |
| Immunogen | Rheumatoid synovial cells and human monocytes |
| Concentration | Lot specific |
| Specificity | CD11b |
| Gene Symbol | ITGAM, ITGAM, ITGAM, ITGAM, ITGAM, ITGAM |
|---|---|
| Gene Full Name | integrin subunit alpha M |
| Alias Symbols | CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6 |
| NCBI Gene Id | 3684; 397459; 454069; 714832; 101004087; 101866035 |
| Protein Name | integrin alpha-M |
| Description of Target | This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Uniprot ID | P11215, A0A1D5QVS1, A0A2K5UU26, H2QB02, A0A2J8J555 |
| Protein Accession # | NP_000623.2 |
| Nucleotide Accession # | NM_000632.3 |
