Human GRIA4 (Glutamate Receptor, Ionotropic, AMPA 4) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	GRIA4
Gene ID:	2893
Uniprot ID:	GRIA4_HUMAN
Sample Type:	tissue homogenates or other biological fluids.

Tissue Specificity
Post Translational Modifications	Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. Phosphorylated at Ser-862 by PRKCG.phosphorylation increases plasma membrane-associated GRI4 expression.
Function	Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
Protein Name	Glutamate Receptor 4 Glur-4 Glur4 Ampa-Selective Glutamate Receptor 4 Glur-D Glutamate Receptor Ionotropic - Ampa 4 Glua4
Database Links	Reactome: R-HSA-399710 Reactome: R-HSA-399719 Reactome: R-HSA-416993 Reactome: R-HSA-438066 Reactome: R-HSA-8849932
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Postsynaptic Cell Membrane Cell Projection Dendrite Interaction With Cnih2 Cnih3 And Prkcg Promotes Cell Surface Expression
Alternative ELISA Names	Glutamate Receptor 4 ELISA kit Glur-4 ELISA kit Glur4 ELISA kit Ampa-Selective Glutamate Receptor 4 ELISA kit Glur-D ELISA kit Glutamate Receptor Ionotropic - Ampa 4 ELISA kit Glua4 ELISA kit GRIA4 ELISA kit GLUR4 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance