Human Metabotropic Glutamate Receptor 6 (GRM6) activation kit by CRISPRa
Referencia GA101971
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Human Metabotropic Glutamate Receptor 6 (GRM6) activation kit by CRISPRa
SKU
GA101971
GRM6 CRISPRa kit - CRISPR gene activation of human glutamate metabotropic receptor 6
2 Weeks*
| Product Data | |
| Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
|---|---|
| Target Symbol | GRM6 |
| Locus ID | 2916 |
| Components | GA101971G1, Metabotropic Glutamate Receptor 6 gRNA vector 1 in [GE100074&pCas-Guide-GFP-CRISPRa] GA101971G2, Metabotropic Glutamate Receptor 6 gRNA vector 2 in [GE100074&pCas-Guide-GFP-CRISPRa] GA101971G3, Metabotropic Glutamate Receptor 6 gRNA vector 3 in [GE100074&pCas-Guide-GFP-CRISPRa] 1 CRISPRa-Enhancer vector, SKU [GE100056] 1 CRISPRa scramble vector, SKU [GE100077] |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
| Reference Data | |
| RefSeq | NM_000843 |
| UniProt ID | O15303 |
| Synonyms | CSNB1B; GPRC1F; mGlu6; MGLUR6 |
| Summary | L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Mutations in this gene result in congenital stationary night blindness type 1B. [provided by RefSeq, May 2018] |
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| SDS |
| SKU | Description | Size | ||
|---|---|---|---|---|
| KN421195 | GRM6 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. | 1 kit | | |
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.