Human Selenophosphate synthetase 2 (SEPHS2) activation kit by CRISPRa
Referencia GA107919
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Human Selenophosphate synthetase 2 (SEPHS2) activation kit by CRISPRa
SKU
GA107919
SEPHS2 CRISPRa kit - CRISPR gene activation of human selenophosphate synthetase 2
2 Weeks*
| Product Data | |
| Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
|---|---|
| Target Symbol | SEPHS2 |
| Locus ID | 22928 |
| Components | GA107919G1, Selenophosphate synthetase 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107919G2, Selenophosphate synthetase 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107919G3, Selenophosphate synthetase 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
| Reference Data | |
| RefSeq | NM_012248 |
| UniProt ID | Q99611 |
| Synonyms | SPS2; SPS2b |
| Summary | This gene encodes an enzyme that catalyzes the production of monoselenophosphate (MSP) from selenide and ATP. MSP is the selenium donor required for synthesis of selenocysteine (Sec), which is co-translationally incorporated into selenoproteins at in-frame UGA codons that normally signal translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is itself a selenoprotein containing a Sec residue at its active site, suggesting the existence of an autoregulatory mechanism. It is preferentially expressed in tissues implicated in the synthesis of selenoproteins and in sites of blood cell development. A pseudogene for this locus has been identified on chromosome 5. [provided by RefSeq, May 2017] |
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| SDS |
| SKU | Description | Size | ||
|---|---|---|---|---|
| KN401830 | SEPHS2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. | 1 kit | | |
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.