IL2 Mouse Monoclonal Antibody [Clone ID: 4F12]

CAT#: SM1540A

IL2 mouse monoclonal antibody, clone 4F12, Azide Free


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Specifications

Product Data
Clone Name 4F12
Applications ELISA, FN
Recommended Dilution ELISA: 5-10 µg as capture antibody.
Functional Assays: 2-20 µg/ml.
Reactivities Chicken, Mammalian, Birds
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen Recombinant Chicken IL-2.
Specificity This antibody SM1540A recognises natural and recombinant IL-2 expressed in either E.coli or CHO cells.
Clone 4F12 neutralises the proliferative activity of rchIL-2 and recognises a different epitope to Clone 10E7 product code (Cat.-No SM1539A).
This antibody can be used as the Neutralising antibody for recombinant Chicken IL-2 bioassays (See Product code SA028).
Formulation PBS without preservatives
State: Azide Free
State: Liquid purified IgG fraction
Stabilizer: None
Concentration lot specific
Purification Affinity Chromatography on Protein G
Conjugation Unconjugated
Storage Store the antibody undiluted at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name interleukin 2
Background Interleukin 2 (IL2) is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. IL2 has been shown to have antitumor effects in some studies. This is probably mediated by cytotoxic effector cells.
Synonyms IL-2, TCGF
Reference Data
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Allograft rejection, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Graft-versus-host disease, Jak-STAT signaling pathway, T cell receptor signaling pathway, Type I diabetes mellitus

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