Melittin, TFA Salt

Referencia 281708-10mg

embalaje : 10mg

Marca : US Biological

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281708 Melittin, TFA Salt

Clone Type
Polyclonal
Grade
Highly Purified
Shipping Temp
RT
Storage Temp
4°C

Apitherapy (the use of honey bee products in alternative medicine) is an emerging field, with a long history of unsupported health benefits, particularly in cancer. Components of bee venom have been demonstrated to have anti-tumoral effects in various cancers. For example, honey bee venom was shown to reduce metastases of breast cancer to the lungs and inhibit tumor growth (Orsolić, et al., 2003). Similarly, the active component of bee venom, a peptide called melittin, showed anticancer selectivity through undefined molecular mechanisms and suggests novel treatment strategies for aggressive breast cancers (Duffy, et al., 2020).||Sequence:|GIGAVLKVLTTGLPALISWIKRKRQQ|(Modification: Gln-26 = C-terminal amide)||Synonyms:|Bee Venom Powder||CAS No:|Free Base: 20449-79-0||Molecular Formula:|C131H229N39O31||Molecular Weight:|2960.48||Appearance:|White to off-white powder||Purity:|≥99%||1H-NMR:|Conforms to reference||Solubility:|Water: 50mg/ml||Storage and Stability:|Store at 4°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Applications
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
Form
White to off-white powder
Purity
≥99%
References
Melitin is the main component of honeybee venom.  It is commonly used as a molecular device for membrane permeabization.  Raghuraman, H; Chattopadhyay, A, Biosci. Rep., 27, 189 (2007); Lee, M-T; et al., Proc. Natl. Acad. Sci. USA, 110, 14243 (2013).