Mouse CX3CL1 (Chemokine C-X3-C-Motif Ligand 1) Sandwich ELISA Kit Ready-To-Use

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	Cx3cl1
Gene ID:	20312
Uniprot ID:	X3CL1_MOUSE
Immunogen Region:	Ready-To-Use
Sample Type:	serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Tissue Specificity	Highest levels in brain. Lower levels in kidney, heart and lung. Also found in skeletal muscle and testis. Highly expressed in lesional smooth muscle cells, but not macrophages. Low levels of ABCD-3 mRNA were also found in anti-CD40-stimulated splenic B-cells, but not in resting B-cells. Also expressed in dendritic cells.
Post Translational Modifications	A soluble short 80 kDa form may be released by proteolytic cleavage from the long membrane-anchored form.
Function	Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1. The CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. Regulates leukocyte adhesion and migration processes at the endothelium. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1. Processed fractalkine: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. Fractalkine: The membrane-bound form promotes adhesion of those leukocytes to endothelial cells.
Protein Name	Fractalkine Fk Abcd-3 C-X3-C Motif Chemokine 1 Cx3c Membrane-Anchored Chemokine Neurotactin Small-Inducible Cytokine D1 Cleaved Into - Processed Fractalkine
Database Links	Reactome: R-MMU-380108 Reactome: -MMU-418594
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Processed Fractalkine: Secreted
Alternative ELISA Names	Fractalkine ELISA kit Fk ELISA kit Abcd-3 ELISA kit C-X3-C Motif Chemokine 1 ELISA kit Cx3c Membrane-Anchored Chemokine ELISA kit Neurotactin ELISA kit Small-Inducible Cytokine D1 Cleaved Into - Processed Fractalkine ELISA kit Cx3cl1 ELISA kit Cx3c ELISA kit Fkn ELISA kit Scyd1 ELISA kit
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Information sourced from Uniprot.org

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