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Mouse Monoclonal Anti-CD7 (T-Cell Leukemia Marker) [Clone B-F12]
Referencia NB-36-00924-P0
embalaje : 20ug
Marca : Neo Biotech
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Printable Datasheet
CD7 (T-Cell Leukemia Marker) Antibody [B-F12]
Catalog Number Formulation Size Price
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
SDS-PAGE Analysis of Purified CD7 Mouse Monoclonal Antibody (Clone B-F12). Confirmation of Integrity and Purity of Antibody.
Applications & Dilutions
Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Flow Cytometry Protocol
Immunofluorescence (IF)
1-3ug/ml
Summary
Recognizes a protein of 40kDa, identified as CD7 (also known as gp40, Leu9). CD7 is a member of the immunoglobulin gene superfamily. Its N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxyl-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3'-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation.
Product Properties & Targets
Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Immunofluorescence
Species Reactivity
Human
Isotype / Light Chain
IgG2a / Kappa
Cellular Localization
Membrane
Gene Name
CD7
Positive Control
CEM cells, HUT-78, Jurkat, Molt-4, or human peripheral blood lymphocytes. Lymph node and tonsil.
Immunogen
Chronic Lymphoid Leukemia cells (CLL)
Alternate Names
T-cell antigen CD7, GP40, T-cell leukemia antigen, T-cell surface antigen Leu-9, TP41, GP40; Leu9; p41; T-cell leukemia antigen; T-cell surface antigen Leu-9; Tp40; TP41
Functions
- Not yet known.
Key References
- Knapp W et al. eds. Leukocyte typing IV, p341, Oxford University Press, Oxford, 1989.
- Miwa H, et al biological characteristics of CD7(+) acute leukemia. Leuk Lymphoma. 1996;21:239-44.
- Rabinowich H, et al. J. Immunol. 1994 153(8):3504-3513.
- Emara M, et al. A human suppressor T-cell factor that inhibits T-cell replication by interaction with the IgM-Fc receptor (CD7). Hum Immunol. 1989;25(2):87-102.
- Saxena A, et al. Biologic and clinical significance of CD7 expression in acute myeloid leukemia. Am J Hematol. 1998;58(4):278-84.
PubMed Links
- https://pubmed.ncbi.nlm.nih.gov/3501369/
- https://pubmed.ncbi.nlm.nih.gov/1703303/
- https://pubmed.ncbi.nlm.nih.gov/15489334/
- https://pubmed.ncbi.nlm.nih.gov/1711009/
- https://pubmed.ncbi.nlm.nih.gov/2479685/
- https://pubmed.ncbi.nlm.nih.gov/10652336/
- https://pubmed.ncbi.nlm.nih.gov/19159218/
- https://pubmed.ncbi.nlm.nih.gov/19349973/
- https://pubmed.ncbi.nlm.nih.gov/19690332/
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
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