Mouse Osteoactivin/GPNMB ELISA Kit
Referencia EA100800
embalaje : 1x96wells
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Mouse Osteoactivin/GPNMB ELISA Kit
| Product Data | |
| ACCN | NM_053110 |
|---|---|
| Assay Length | 3.5 hours incubations; 1 hour washing and analyzing samples |
| Assay Platform | 96-well plate |
| Assay Type | Sandwich ELISA kit of Quantitative Detection for Mouse Osteoactivin/GPNMB |
| Assay Type | Sandwich |
| Background | Transmembrane glycoprotein NMB is a protein that is encoded by the GPNMB gene. In osteoblast progenitor cells, GPNMB works as a positive regulator of osteoblast differentiation during later stages of matrix maturation and mineralization that is mediated at least in part by BMP-2 in a SMAD1 dependent manner to promote osteoblast differentiation. GPNMB can enhance the repairing process in bone fracture, demonstrated by its high expression during chondrogenesis(soft callus) and osteogenesis(hard callus) compared to the intact femurs that is why Osteoactivin(OA) could be a novel therapeutic agent used to treat generalized osteoporosis or localized osteopenia during fracture repair by stimulating bone growth and regeneration. Similarly, GPNMB expression increases during osteoclast differentiation and it is functionally implicated in this process, possibly by promoting the fusion of osteoclast progenitor cells. |
| Components |
|
| Cross Reactivity | There is no detectable cross-reactivity with other relevant proteins. |
| Curve Range | 156pg/ml-10,000pg/ml |
| Gene Symbol | Gpnmb |
| Interference | No significant interference observed with available related molecules. |
| Locus ID | 93695 |
| Reactivity | Mouse |
| Reactivity | Mouse |
| Reactivity | Mouse |
| Sample Type | Cell culture supernates, serum and plasma(heparin, EDTA). |
| Sample Volume | 100 ul |
| Sensitivity | <10pg/ml |
| Signal | Colorimetric |
| Species | Mouse |
| Specificity | This kit is used for quantitative detection of mouse Osteoactivin |
| Target Symbol | Gpnmb |
| New | No |
| Description | Mouse Osteoactivin/GPNMB ELISA Kit |