Mouse VLDLR (Very Low Density Lipoprotein Receptor) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	Vldlr
Gene ID:	22359
Uniprot ID:	VLDLR_MOUSE
Sample Type:	tissue homogenates or other biological fluids.

Tissue Specificity	Abundant in heart and muscle.less in kidney, brain, ovary, testis, lung and adipose tissue. Strongly expressed in neurons.
Post Translational Modifications	Ubiquitinated at Lys-839 by MYLIP leading to degradation.
Function	Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism. Binds also to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE-containing ligands as well as clusterin/CLU. In the off-state of the pathway LRP8 and VLDLR form homo or heterooligomers. Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 on its cytoplasmic tail. This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons. Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone.
Protein Name	Very Low-Density Lipoprotein Receptor Vldl Receptor Vldl-R
Database Links	Reactome: R-MMU-8866376 Reactome: -MMU-8866427 Reactome: -MMU-8964046
Cellular Localisation	Membrane Single-Pass Type I Membrane Protein Clathrin-Coated Pit
Alternative ELISA Names	Very Low-Density Lipoprotein Receptor ELISA kit Vldl Receptor ELISA kit Vldl-R ELISA kit Vldlr ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance