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> Phosphatidylserine [1446756-47-3]

Phosphatidylserine [1446756-47-3]

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Phosphatidylserine (Phospholipids) is a well-conserved anti-inflammatory and immunosuppressive signal. Phosphatidylserine is involved in membrane translocation and the activation of protein kinase C, participating in Akt signaling through its interaction with PIP3. The local exposure of Phosphatidylserine can interact with complement and other proteins, promoting microglial phagocytosis during critical periods of synaptic refinement. Phosphatidylserine can promote blood coagulation in the extracellular environment and acts as a "eat me" signal to clear out apoptotic cells. Phosphatidylserine can suppress inflammation in tissues by inducing TGF-β secretion and inhibiting immune responses.

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Phosphatidylserine Estructura química

Phosphatidylserine Estructura química

No. CAS : 1446756-47-3

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Based on 1 publication(s) in Google Scholar

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Descripciòn

Phosphatidylserine (Phospholipids) is a well-conserved anti-inflammatory and immunosuppressive signal. Phosphatidylserine is involved in membrane translocation and the activation of protein kinase C, participating in Akt signaling through its interaction with PIP3. The local exposure of Phosphatidylserine can interact with complement and other proteins, promoting microglial phagocytosis during critical periods of synaptic refinement. Phosphatidylserine can promote blood coagulation in the extracellular environment and acts as a "eat me" signal to clear out apoptotic cells. Phosphatidylserine can suppress inflammation in tissues by inducing TGF-β secretion and inhibiting immune responses[1][2][3][4][5].
In Vitro

Phosphatidylserine can inhibit inflammation in tissues by inducing TGF-β secretion, thereby avoiding activation of immune responses through the production of regulatory T cells[2].
Phosphatidylserine can promote neuronal survival, differentiation, and synaptic neurotransmission[3].
Phosphatidylserine mediates the pruning of microglia developmental synapses when undergoing local externalization[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Phosphatidylserine Related Antibodies
In Vivo

Phosphatidylserine, after forming liposomes with PC and cholesterol in a molar ratio of 30:30:40 (0.5 mg liposome; single dose; s.c.), can inhibit immune responses in vivo by binding to and enhancing the activation of the Phosphatidylserine receptor[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/cAnN and C57BL/6 male mice[2].
Dosage: Phosphatidylserine (PS) liposomes (0.5 mg of total lipid, PS-containing liposomes consisted of 30:30:40 molar ratio PS to PC to cholesterol)
Administration: Subcutaneous injection (s.c.); single dose
Result: Inhibited responses to Ags as determined by decreased draining lymph node tissue mass, with reduced numbers of total leukocytes and Ag-specific CD4+ T cells.
Ensayo clínico
Peso molecular

788.10

No. CAS

1446756-47-3
Appearance

Liquid

Color

Light yellow to yellow

SMILES

[Phosphatidylserine]
Initial Source
  • Animals

Most organisms
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Solution, -20°C, 2 years
Pureza y Documentación

Purity: ≥98.0%

COA (242 KB)

Instrucciones de manejo (2659 KB)
Referencias

  • [1]. Kay JG, et al. Phosphatidylserine-mediated cellular signaling. Adv Exp Med Biol. 2013;991:177-93.  [Content Brief]

    [2]. Hoffmann PR, et al. Interaction between phosphatidylserine and the phosphatidylserine receptor inhibits immune responses in vivo. J Immunol. 2005 Feb 1;174(3):1393-404.  [Content Brief]

    [3]. Kim HY, et al. Phosphatidylserine in the brain: metabolism and function. Prog Lipid Res. 2014 Oct;56:1-18.  [Content Brief]

    [4]. Scott-Hewitt N, et al. Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia. EMBO J. 2020 Aug 17;39(16):e105380.  [Content Brief]

    [5]. Huang BX, et al. Phosphatidylserine is a critical modulator for Akt activation. J Cell Biol. 2011 Mar 21;192(6):979-92.

  • [1]. Kay JG, et al. Phosphatidylserine-mediated cellular signaling. Adv Exp Med Biol. 2013;991:177-93.

    [2]. Hoffmann PR, et al. Interaction between phosphatidylserine and the phosphatidylserine receptor inhibits immune responses in vivo. J Immunol. 2005 Feb 1;174(3):1393-404.

    [3]. Kim HY, et al. Phosphatidylserine in the brain: metabolism and function. Prog Lipid Res. 2014 Oct;56:1-18.

    [4]. Scott-Hewitt N, et al. Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia. EMBO J. 2020 Aug 17;39(16):e105380.

    [5]. Huang BX, et al. Phosphatidylserine is a critical modulator for Akt activation. J Cell Biol. 2011 Mar 21;192(6):979-92.

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Phosphatidylserine Related Classifications

  • Inflammation/Immunology
  • PI3K/Akt/mTOR TGF-beta/Smad
  • Akt TGF-β Receptor

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Keywords:

Phosphatidylserine1446756-47-3Phospholipids, phosphatidylserines Serine glycerophosphatidesAktTGF-β ReceptorPKBProtein kinase BTransforming growth factor beta receptorsantiinflammatoryimmunosuppressionlocalized exposurecell phagocytosisInhibitorinhibitorinhibit