General Info
| Applications: | Immunodepletion/Immunocompetition |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Prostaglandin E Receptor EP2 Blocking Peptide is synthetically produced from the 300-350 sequence and is suitable for use in western blot applications. |
| Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Information
| Gene Symbol: | PTGER3 |
| Gene ID: | 5733 |
| Uniprot ID: | PE2R3_HUMAN |
| Immunogen Region: | 300-350 |
| Immunogen: | Synthetic peptide taken within amino acid region 300-350 on human Prostaglandin E2 receptor EP3 subtype. |
Description
| Tissue Specificity | Detected in kidney. Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels. |
| Function | Receptor for prostaglandin E2 (PGE2). The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(i) proteins, and to an elevation of intracellular calcium. Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality. |
| Peptide Name | Prostaglandin E2 Receptor Ep3 SubtypePge Receptor Ep3 SubtypePge2 Receptor Ep3 SubtypePge2-RProstanoid Ep3 Receptor |
| Database Links | Reactome: R-HSA-391908Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Peptide Names | Prostaglandin E2 Receptor Ep3 Subtype proteinPge Receptor Ep3 Subtype proteinPge2 Receptor Ep3 Subtype proteinPge2-R proteinProstanoid Ep3 Receptor proteinPTGER3 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance