Recombinant Human 4-1BB Ligand/TNFSF (E.coli,C-6His)

Biological Activity

Species: Human
Expression system: E.coli
Purity: > 95% as determined by reduced SDS-PAGE
Endotoxin: less than 0.1 ng/ug (1 EU/ug) as tested by LAL
Storage and stability: Lyophilized proteins should be stored at < -20°C but can be stored at room temperature for up to 3 weeks. The recombinant protein solution can be stored at 4-7℃ for 2-7 days. The isometric solution of the recombinant sample was stable at < -20°C for 3 months.


Bioactivity: Tumor necrosis factor ligand superfamily member 9(4-1BBL) is a unipassable type II membrane protein, a member of the tumor necrosis factor family. 4-1BBL is a 254-amino acid cytokine expressed in the brain, placenta, lung, skeletal muscle and kidney. TNFSF9 has been shown to reactivate incompetent T lymphocytes in addition to promoting T cell proliferation. This cytokine may play a role in the activation of induced cell death (AICD) and homologous interactions between T cells and B cells/macrophages. It has also been shown to be essential for optimal CD8 responses in CD8 T cells and is thought to be involved in T-cell - tumor cell interactions.

Chemical Information