RNF144B Polyclonal Antibody, HRP Conjugated
Referencia bs-7613R-HRP
embalaje : 100ul
Marca : Bioss
RNF144B Polyclonal Antibody, HRP Conjugated
Applications
Predicted Reactivity
Overview | |
Catalog # | bs-7613R-HRP |
Product Name | RNF144B Polyclonal Antibody, HRP Conjugated |
Applications | ELISA, IHC-P, IHC-F |
Predicted Reactivity | Human, Mouse, Rat, Dog, Cow, Sheep, Pig, Horse, Chicken, Cat, Rabbit, Guinea Pig |
Specifications | |
Conjugation | HRP |
Host | Rabbit |
Source | KLH conjugated synthetic peptide derived from human IBRDC2/RING finger protein 144B |
Immunogen Range | 218-303/303 |
Clonality | Polyclonal |
Isotype | IgG |
Concentration | 1ug/ul |
Purification | Purified by Protein A. |
Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
Target | |
Gene ID | 255488 |
Subcellular location | Cytoplasm, Cell membrane |
Synonyms | E3 ubiquitin protein ligase RNF144B; RING finger protein 144B; E3 ubiquitin-protein ligase RNF144B; IBR domain containing 2; IBR domain containing protein 2; IBR domain-containing protein 2; IBRDC 2; IBRDC2; p53 inducible RING finger protein; p53-inducible RING finger protein; p53RFP; PIR2; R144B_HUMAN; Ring finger 144B; RING finger protein 144B; RNF 144B; RNF144B. |
Background | E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.Tissue specificity: Broadly expressed, with lowest levels in brain and thymus, and highest levels detectable in heart, ovary and testis. |
Application Dilution | |
ELISA | 1:500-1000 |
IHC-P | 1:200-400 |
IHC-F | 1:100-500 |