H00006334-M04 | SCN8A monoclonal antibody (M04), clone 4G7 Clinisciences

Specifications

Product Description

Mouse monoclonal antibody raised against a partial recombinant SCN8A.MAB,monoclonal Ab,monoclonal antibody

Immunogen

SCN8A (NP_055006, 1854 a.a. ~ 1951 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence

RVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICKKTTSNKLENGGTHREKKESTPSTASLPSYDSVT

Host

Mouse

Reactivity

Human

Interspecies Antigen Sequence

Mouse (98); Rat (96)

Isotype

IgG2a Kappa

Quality Control Testing

Antibody Reactive Against Recombinant Protein.

Western Blot detection against Immunogen (36.52 KDa) .

Storage Buffer

In 1x PBS, pH 7.4

Storage Instruction

Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

Applications

Western Blot (Recombinant protein)

Protocol Download

Sandwich ELISA (Recombinant protein)

Detection limit for recombinant GST tagged SCN8A is 0.03 ng/ml as a capture antibody.

Protocol Download

ELISA

Immunofluorescence

Immunofluorescence of monoclonal antibody to SCN8A on NIH/3T3 cell. [antibody concentration 10 ug/ml]

Protocol Download

Gene Info A

Entrez GeneID

6334

GeneBank Accession#

NM_014191

Protein Accession#

NP_055006

Gene Name

SCN8A

Gene Alias

CerIII, MED, NaCh6, Nav1.6, PN4

Gene Description

sodium channel, voltage gated, type VIII, alpha subunit

Omim ID

600702

Gene Ontology

Hyperlink

Gene Summary

Voltage-dependent sodium channels, such as SCN8A, are responsible for the initial membrane depolarization that occurs during generation of action potentials in most electrically excitable cells (Plummer et al., 1998 [PubMed 9828131]).[supplied by OMIM

Other Designations

Interactomes

SCN8A

Diseases

Publication Reference

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.
Ogiwara I, Miyamoto H, Morita N, Atapour N, Mazaki E, Inoue I, Takeuchi T, Itohara S, Yanagawa Y, Obata K, Furuichi T, Hensch TK, Yamakawa K.

Journal of Neuroscience 2007 May; 27(22):5903.

Application：WB, Mouse, Mouse brain.

SCN8A monoclonal antibody (M04), clone 4G7

Referencia H00006334-M04

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Marca : Abnova

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Product Description

Immunogen

Sequence

Host

Reactivity

Interspecies Antigen Sequence

Isotype

Quality Control Testing

Storage Buffer

Storage Instruction

Western Blot (Recombinant protein)

Sandwich ELISA (Recombinant protein)

ELISA

Immunofluorescence

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

Gene Alias

Gene Description

Omim ID

Gene Ontology

Gene Summary

Other Designations

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