Our USP6 break apart probe is designed to detect USP6 translocations. The probe comes labeled in orange and green, but can be customized to meet your needs. 

Gene Background: USP6 encodes a ubiquitin-specific peptidase, which functions in removing ubiquitin from target proteins.1 De-ubiquitination is a widely used post-transcriptional regulatory mechanism that regulates protein stability in order to maintain normal chemical signaling and permeability in intercellular junctions.1 In normal cells, USP6 uses de-ubiquitination to drive important homeostatic processes, like DNA damage response, protein turnover, and vesicular trafficking.1 USP6’s cancer-causing properties were first discovered over 2 decades ago, when its translocation was found to promote pathogenesis in Ewing’s sarcoma.2 USP6 rearrangements have also been found to contribute to tumor growth in the human neoplasms nodular fasciitis (NF) and aneurysmal bone cyst (ABC).2

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Gene Summary

The Ubiquitin Specific Peptidase 6 (USP6) gene is located on chr17:5031686 -5078324 at 17p13.2.

Gene Details

Gene Symbol: USP6

Gene Name: Ubiquitin Specific Peptidase 6

Chromosome: CHR17: 5031686-5078324

Locus: 17p13.2

References

Benign spindle cell lesions of the breast: a diagnostic approach to solitary fibrous tumour, nodular pseudoangiomatous stromal hyperplasia and nodular fasciitis

Benign spindle cell lesions of the breast are a rare and varied subset of lesions that can be difficult to distinguish from other tumor types. This study presented three different cases of benign spindle cell lesions - solitary fibrous tumor (SFT), nodular pseudoangiomatous stromal hyperplasia (PASH) and nodular fasciitis (NF) - and highlighted the different histological and cytogenetic techniques that could be used to identify them. Empire Genomics’ USP6 break-apart probe was used to test breast tissue biopsies for rearrangements in the USP6 gene, which has been found to occur in more than 90% of NF cases. Researchers recommended using FISH to help diagnose future cases where NF is suspected but can’t be solely determined through morphological or immunohistochemical means.