Anti-Stra6 antibody (200-300) {Biotin}

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.69 µg/µl
Dilution Range:	WB: 1:500 ELISA: 1:10, 000 IP: 1:200 IHC: 1:100
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	Stra6
Gene ID:	20897
Uniprot ID:	STRA6_MOUSE
Immunogen Region:	200-300
Immunogen:	Synthetic peptide taken within third large intra cytoplasmic loop within amino acid region 200-300 on rat Stra6 protein.

Tissue Specificity	Widely expressed in the embryo. Detected in adult in the retinal pigment epithelium in the eye. In the adult, is highly expressed in cells that compose blood-organ barriers in the brain (choroid plexus and the brain microvascular), in testis (the basal layer of the seminiferous epithelium), in the yolk sac, and in the chorioallantoic placenta. Detected in white adipose tissue and skeletal muscle, but not in liver (at protein level). Widely expressed in adult, with high expression levels in the eye. Detected in brain, cerebellum, testis, pituitary, pancreas, kidney, spleen, and female genital tract.and at very low levels in heart and lung. Not detected in liver.
Post Translational Modifications	Phosphorylated on tyrosine residues in response to RBP4 binding. Phosphorylation requires the presence of LRAT, suggesting it may be triggered by the uptake of retinol that is then metabolized within the cell to retinoids that function as signaling molecules.
Function	Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1. Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A. Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin. Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid and 11-cis-retinal. STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency. Does not transport retinoic acid.
Protein Name	Receptor For Retinol Uptake Stra6 Retinoic Acid-Responsive Protein Retinol-Binding Protein Receptor Stra6 Stimulated By Retinoic Acid Gene 6 Protein
Database Links	Reactome: R-MMU-2453902
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein In The Retinal Pigment Epithelium Localizes To The Basolateral Membrane Plasma Membrane Of The Basal Pole Of Sertoli Cells Absent In Plasma Membrane Of Neighboring Spermatogonia
Alternative Antibody Names	Anti-Receptor For Retinol Uptake Stra6 antibody Anti-Retinoic Acid-Responsive Protein antibody Anti-Retinol-Binding Protein Receptor Stra6 antibody Anti-Stimulated By Retinoic Acid Gene 6 Protein antibody Anti-Stra6 antibody

Information sourced from Uniprot.org

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