CD86 (T-lymphocyte Activation Antigen CD86, Activation B7-2 Antigen, B70, BU63, CTLA-4 Counter-receptor B7.2, FUN-1, CD28LG2)

Referencia C2438-26G-100ug

embalaje : 100ug

Marca : US Biological

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C2438-26G CD86 (T-lymphocyte Activation Antigen CD86, Activation B7-2 Antigen, B70, BU63, CTLA-4 Counter-receptor B7.2, FUN-1, CD28LG2)

Clone Type
Polyclonal
Host
mouse
Source
human
Isotype
IgG2b,k
Grade
Affinity Purified
Applications
FC IHC WB
Crossreactivity
Hu
Shipping Temp
Blue Ice
Storage Temp
-20°C

CD86 is an 80 kD immunoglobulin superfamily member, also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, monocytes/macrophages, dendritic cells and astrocytes. CD86 along with CD80 are the ligands of CD28 and CD152 (CTLA-4). CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce co-stimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CD152, known as CTLA-4, to deliver an inhibitory signal to T cells. The IT2.2 antibody blocks T cell activation.||Applications:|Suitable for use in Flow Cytometry, Western Blot and Immunohistochemistry. Other applications not tested.||Recommended Dilution:|Optimal dilutions to be determined by the researcher.||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Applications
Product Type: Mab|Isotype: IgG2b, k|Clone No: IT2.2|Host: mouse|Source: human|Concentration: ~0.5mg/ml|Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.|Purity: Purified by immunoaffinity chromatography.|Immunogen: Human CD86|Specificity: Recognizes human CD86. Species Crossreactivity: chimpanzee, baboon, cynomolgus, rhesus.||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Immunogen
Human CD86
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human CD86. Species Crossreactivity: chimpanzee, baboon, cynomolgus, rhesus.
References
1. Kishimoto, T., et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing, Inc. London. 2. Dieu, M. 1998. J. Exp. Med. 188:373. 3. Esser, M. et al. 2001. J. Virol. 75:6173. 4. Jeannin, P. et al. 1999. J. Immunol. 162:2044. 5. Kapsogeorgou, E. K. et al. 2001. J. Immunol. 166:3107. 6. Geissmann, F.,et al. 2001. Blood 97:1241. 7. Jakyakumar, A., et al. 2008. Infect Immun. 76:2138. 8. Zaba, LC.,et al. 2007. J Exp Med. 204:3183. 9. Hathcock, K., et al. 1996. Adv. Immunol. 62:131. 10. June, C., et al. 1994. Immunol. Today 15:321.