Dapagliflozin [461432-26-8]
Referencia T2389-5mg
embalaje : 5mg
Marca : TargetMol
Dapagliflozin
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Purity:99.74%
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COA HNMR HPLC
Dapagliflozin
Catalog No. T2389Cas No. 461432-26-8
Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. Pack Size | |
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5 mg | |
10 mg | |
25 mg | |
50 mg | |
100 mg | |
200 mg | |
1 mL x 10 mM (in DMSO) |
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
Description | Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity. |
Targets&IC50 | SGLT2 (human):1.1 nM(EC50) |
In vitro | METHODS: The human proximal tubule epithelial cell line HK2 was treated with Dapagliflozin (1-10 µM) under normoxic and hypoxic conditions for 24 h. Cell viability was assayed using Trypan blue staining. RESULTS: Dapagliflozin pretreatment had no effect on cell survival of normoxic HK2 cells. Hypoxia significantly reduced the cell viability of HK2 cells compared to control cells, and Dapagliflozin pretreatment of hypoxic HK2 cells significantly increased cell viability in a dose-dependent manner. [1] METHODS: The human proximal tubule epithelial cell line HK2 was treated with Dapagliflozin (0.1 µM) and H2O2 (200 µM) for 24 h. Apoptosis was detected using Hoechst 33342 and PI. RESULTS: Dapagliflozin significantly reduced the percentage of apoptotic cell death induced by H2O2.Dapagliflozin had a protective effect against H2O2-induced cell death. [2] |
In vivo | METHODS: To investigate the effects on diabetic atherosclerosis, Dapagliflozin (1 mg/kg) was administered by gavage to diabetic ApoE-/- mice with high-fat diet-induced atherosclerosis once daily for 12 weeks. RESULTS: Dapagliflozin may have therapeutic potential for high-fat diet-induced diabetic atherosclerosis, and these benefits may depend on the inhibition of IL-1β secretion by macrophages via the ROS-NLRP3-caspase-1 pathway. [3] |
Cell Research | To perform the cell survival assay, cells are collected after 24 h incubation with vehicle or dapagliflozin pretreatment in 30-min ischemia and surviving cells are counted with Trypan blue staining. The percentage survival is determined by quantization of the relative viable number of treated cells divided by the viable number of untreated cells. |
Alias | BMS-512148 |
Molecular Weight | 408.87 |
Formula | C21H25ClO6 |
Cas No. | 461432-26-8 |
Storage | store at low temperature,store under nitrogen,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 14 mg/mL (34.2 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 45 mg/mL (110.06 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSO
main solution, add 300 μLPEG300
mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O
mix well and clarify
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
BMS512148Sodium-dependent glucose cotransportersSGLTinhibitBMS 512148InhibitorDapagliflozin
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