Human IMPDH2 (Inosine 5 Monophosphate Dehydrogenase 2) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	IMPDH2
Gene ID:	3615
Uniprot ID:	IMDH2_HUMAN
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	IMPDH1 is the main species in normal leukocytes and IMPDH2 predominates over IMPDH1 in the tumor.
Post Translational Modifications	Ubiquitinated leading to its degradation by the proteasome. The N-terminus is blocked. Acetylated by CLOCK in a circadian manner.
Function	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Protein Name	Inosine-5'-Monophosphate Dehydrogenase 2 Imp Dehydrogenase 2 Impd 2 Impdh 2 Inosine-5'-Monophosphate Dehydrogenase Type Ii Imp Dehydrogenase Ii Impdh-Ii
Database Links	Reactome: R-HSA-6798695 Reactome: R-HSA-73817 Reactome: R-HSA-9679191 Reactome: R-HSA-9748787
Cellular Localisation	Cytoplasm Nucleus Cytosol Can Form Fiber-Like Subcellular Structures Termed 'Cytoophidia' In Response To Intracellular Guanine-Nucleotide Depletion
Alternative ELISA Names	Inosine-5'-Monophosphate Dehydrogenase 2 ELISA kit Imp Dehydrogenase 2 ELISA kit Impd 2 ELISA kit Impdh 2 ELISA kit Inosine-5'-Monophosphate Dehydrogenase Type Ii ELISA kit Imp Dehydrogenase Ii ELISA kit Impdh-Ii ELISA kit IMPDH2 ELISA kit IMPD2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance