Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	RYR2
Gene ID:	6262
Uniprot ID:	RYR2_HUMAN
Sample Type:	tissue homogenates or other biological fluids.

Tissue Specificity	Detected in heart muscle (at protein level). Heart muscle, brain (cerebellum and hippocampus) and placenta.
Post Translational Modifications	Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2808 and Ser-2814 increases the open probability of the calcium channel. Phosphorylation is increased in failing heart, leading to calcium leaks and increased cytoplasmic Ca(2+) levels. Phosphorylation at Ser-2031 by PKA enhances the response to lumenal calcium.
Function	Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) cytosolic levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.
Protein Name	Ryanodine Receptor 2 Ryr-2 Ryr2 Hryr-2 Cardiac Muscle Ryanodine Receptor Cardiac Muscle Ryanodine Receptor-Calcium Release Channel Type 2 Ryanodine Receptor
Database Links	Reactome: R-HSA-2672351 Reactome: R-HSA-5578775
Cellular Localisation	Sarcoplasmic Reticulum Membrane Multi-Pass Membrane Protein
Alternative ELISA Names	Ryanodine Receptor 2 ELISA kit Ryr-2 ELISA kit Ryr2 ELISA kit Hryr-2 ELISA kit Cardiac Muscle Ryanodine Receptor ELISA kit Cardiac Muscle Ryanodine Receptor-Calcium Release Channel ELISA kit Type 2 Ryanodine Receptor ELISA kit RYR2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance