IL1 beta (IL1B) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, FN, WB
Recommended Dilution	ELISA. Western Blot: Detects a band of approximately 29kDa in HD-11 cell lysates transfected with chIL-1. Functional Assays.
Reactivities	Chicken
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinaint Chicken IL-1B
Specificity	This antibody recognizes Chicken Interleukin 1 beta (chIL-1beta), which shares homology with Mammalian IL-1 beta. Other species not tested. This antibody neutralizes IL-1 beta (Ref.1-2).
Formulation	PBS State: Azide Free State: Liquid purified IgG fraction Stabilizer: None Preservative: None
Concentration	lot specific
Purification	Affinity Chromatography on protein G
Conjugation	Unconjugated
Storage	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Gene Name	interleukin 1 beta
Database Link	Entrez Gene 3553 Human UniProt ID P01584
Background	IL-1 is a major regulator in both innate and adaptive immune responses, plays an important role in the regulation of acute inflammation and has also been implicated in many other processes, including both fever and fibrinogen induction. The previous names by which IL-1 has been known includes lymphocyte activating factor, endogenous pyrogen, catabolin, hemopoietin-1, melanoma growth inhibition factor, and osteoclast activating factor, reflecting its widespread cell expression. Studies using chicken models have indicated physiological similarities between chIL-1beta and mammalian IL-1beta in relation to its neural distribution and several factors have been shown to induce chIL-1beta secretion, including protein kinase C (PKC), Calmodulin-dependent protein kinase, lipopolysaccharide, phorbol esters, calcium and silica.
Synonyms	IL-1 beta, IL1B, IL1 beta, IL1F2, Catabolin
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Alzheimer's disease, Apoptosis, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Graft-versus-host disease, Hematopoietic cell lineage, MAPK signaling pathway, NOD-like receptor signaling pathway, Prion diseases, Toll-like receptor signaling pathway, Type I diabetes mellitus