Mouse Anti-Human TIMP-4-UNLB
Referencia 12035-01
embalaje : 0.1mg
Marca : Southern Biotech
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Teléfono : +1 850 650 7790
| Clone | SB30c |
|---|---|
| Isotype | Mouse (BALB/c) IgG2aκ |
| Isotype Control | Mouse IgG2a-UNLB (HOPC-1) |
| Specificity | Human/Mouse/Rat TIMP-4 |
| Alternative Names | Tissue inhibitor of metalloproteinase 4 |
| Description | Tissue inhibitors of matrix metalloproteinases (TIMPs) constitute a family of secreted multifunctional proteins which are classified based on structural similarity to each other as well as their ability to inhibit matrix metalloproteinases (MMPs). TIMPs play a critical role in ECM homeostasis but have also been shown to have erythroid-potentiating and cell growth-promoting activities. TIMP-4, unlike TIMP-1, TIMP-2 and TIMP-3, shows restricted localization to cardiac, neural, breast, and muscle tissue. Cardiospecific TIMP-4 seems to play a significant role in regulating the normal cell phenotype since reduced levels elicit cellular transformation. |
| Immunogen | Recombinant human TIMP-4 (a.a. 35-224) |
| Conjugate | UNLB (Unconjugated) |
| Buffer Formulation | Borate buffered saline, pH 8.2 |
| Clonality | Monoclonal |
| Concentration | 0.5 mg/mL |
| Volume | 0.2 mL |
| Recommended Storage | 2-8°C |
| Applications | Western Blot – Quality tested 1-3 Immunohistochemistry-Paraffin Sections 4 Immunocytochemistry 4 ELISA 5 |
| RRID Number | AB_2794707 |
| Gene ID | 7079 (Human) 110595 (Mouse) 680130 (Rat) |
| Gene ID Symbol | TIMP4 (Human) Timp4 (Mouse) Timp4 (Rat) |
| Gene ID Aliases | TIMP-4; Timp-4 |
| UniProt ID | Q99727 (Human Q9JHB3 (Mouse P81556 (Rat |
| UniProt Name | TIMP4_HUMAN (Human) TIMP4_MOUSE (Mouse) TIMP4_RAT (Rat) |
Documentation
Technical Bulletin Safety Datasheet
Certificate of Analysis Lookup
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- 1. Alarab M, Kufaishi H, Lye S, Drutz H, Shynlova O. Expression of extracellular matrix-remodeling proteins is altered in vaginal tissue of premenopausal women with severe pelvic organ prolapse. Reprod Sci. 2014;21:704-15. (WB)
- 2. Zambirinis CP, Levie E, Nguy S, Avanzi A, Barilla R, Xu Y, et al. TLR9 ligation in pancreatic stellate cells promotes tumorigenesis. J Exp Med. 2015;212:2077-94. (WB, Mouse Reactivity)
- 3. Ketsawatsomkron P, Keen HL, Davis DR, Lu K, Stump M, De Silva TM, et al. Protective role for tissue inhibitor of metalloproteinase-4, a novel peroxisome proliferator-activated receptor-γ target gene, in smooth muscle in deoxycorticosterone acetate-salt hypertension. Hypertension. 2016;67:214-22. (WB, Mouse & Rat Reactivity)
- 4. SouthernBiotech published data (IHC-PS, ICC)
- 5. SouthernBiotech unpublished data (ELISA)