Reactivos e instrumentos para inmunología, biología celular y biología molecular.

Tumor Necrosis Factor- alpha Variant; human TNF-α Variant

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embalaje : 10ug

Teléfono : +1 850 650 7790

Teléfono : +1 850 650 7790

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Storage: (-15 to -20)C

: Product Description: TNF alpha Variant, Tumor Necrosis Factor-alpha Variant, human: The clinical use of the potent antitumor activity of TNF-αhas been limited by the proinflammatory side effects including fever, dose-limiting hypotension, hepatotoxicity, intravascular thrombosis, and hemorrhage. Designing clinically applicable TNF-αmutants with low systemic toxicity has been an intense pharmacological interest. Human TNF-α, which binds to the murine TNF-R55 but not to the murine TNF-R75, exhibits retained antitumor activity and reduced systemic toxicity in mice compared with murine TNF-α, which binds to both murine TNF receptors. Based on these results, many TNF-αmutants that selectively bind to TNF-R55 have been designed. These mutants displayed cytotoxic activities on tumor cell lines in vitro, and exhibited lower systemic toxicity in vivo., UnitProt ID: P01375

Number of Containers: 1

Refrigeration Requirements: Freezer

Shipping Conditions: ICE

UNSPSC Code: 41116127

UNSPSC Category: Other Cytokines and Chemokines
Documents: Product Info. (42.29 KB)

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