Angene

 
Angene se compromete a proporcionar productos químicos de calidad para su uso en investigación y desarrollo y fabricación comercial. Angene ofrece más de 100.000 productos, incluidos reactivos de laboratorio, bloques de construcción, intermediarios, productos básicos a granel, productos agroquímicos, ingredientes naturales e ingredientes farmacéuticos activos (API). Además de los más de 100.000 productos, Angene ofrece síntesis personalizadas de productos químicos que no están disponibles comercialmente.

 

 
 
 
SARS-CoV-2 - Baricitinib - Therapeutic Candidates

SARS-CoV-2 - Baricitinib - Therapeutic Candidates


Like ruxolitinib, baricitinib (OLUMIANT) is an inhibitor of Janus kinase 1 (JAK1) and Janus kinase 2 (JAK2) which are tyrosine kinases involved in JAK signaling pathways. Baricitinib is a reversible and selective inhibitor and is indicated in the treatment of moderate to severe active rheumatoid arthritis for its anti-inflammatory effect. It is a second-line therapy, i.e., used after failure of conventional disease-modifying therapies. It can be used alone or in combination with methotrexate (MTX).
A clinical study on the efficacy and safety of baricitinib for the treatment of Covid-19 has begun. The anti-inflammatory activity of this drug may have a potential beneficial effect in the treatment of Covid-19. The use of baritinicib therapy may limit the cytokine release syndrome associated with Covid-19 and may be useful because it acts against a wide range of cytokines.

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