![3D scaffold for tumor cells - Black plates (Fluorescence)](https://www.clinisciences.com/es/upload/thumbs/bandeau3-vmxy9u-8f6d44.png)
3D scaffold for tumor cells - Black plates (Fluorescence)
Extracellular matrix (ECM) is a complex viscoelastic system composed of various distinct components (GAG, Collagen…) that are often organized into a fibrillar microstructure.
The physicochemical properties (composition and architecture) of the ECM play a critical role in regulating important cellular functions such as spreading, migration, proliferation, and differentiation.
To better mimic the tumor microenvironment, BIOMIMESYS® Oncology is a double interpenetrating network (IPN) hydroscaffold based on Hyaluronic acid (HA) and type I collagen crosslinked with Adipic acid dihydrazid (ADH).
Spheroid growth, Viability, Cell proliferation
BIOMIMESYS® Oncology hydroscaffold provides cell binding sites with CD44 and RHAMM allowing cell-matrix and cell-cell interactions.
Cancer cells growing in BIOMIMESYS® Oncology hydrscaffold proliferate and aggregate to form spheroids from the 5th day of culture. The size and formation of the spheroids varies as a function of:
- Seeding density
- Length of culture
- Cell type
The cells can be cultured for at least 28 days.
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Precio Sin IVA
BIO_ONC_96_96_B10
10plates/96wellsfilled
BIO_ONC_96_24_black
1plate/24wellsfilled
BIO_ONC_96_96_black
1plate/96wellsfilled
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