GLYcoDiag
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GLYcoDiag es una empresa de investigación y desarrollo especializada en glicociencias que ofrece servicios y productos para los campos de la salud (biomarcadores, glicoproteínas recombinantes terapéuticas, vacunas), la cosmética (principios activos, diseño y mecanismos de "glicoactivos") y el medio ambiente (biopelículas, aguas residuales).
Desde 2015, GLYcoDiag desarrolla su propia gama de reactivos y kits para usos de investigación:
Lectinas naturales y recombinantes
Neoglicoproteínas y neoglicoclusters
Geles LEctPROFILE®, geles CarbPROFILE Kits LEctPROFILE® (kits basados en lectinas destinados al cribado / comparación / detección de ligandos) Página web: www.glycodiag.com
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![Narcissus pseudonarcissus Lectin (NPL/NPA)](https://www.clinisciences.com/es/upload/thumbs/narcissus-pseudonarcissus-lent-li-mmaute-bb164f.jpg)
Narcissus pseudonarcissus Lectin (NPL/NPA)
Narcissus pseudonarcissus lectin or agglutinin (NPL/NPA) is isolated from wild daffodils. This lectin is composed of four subunits and has a molecular weight of 59 kDa. It agglutinates rabbit erythrocytes but is non-reactive with human erythrocytes. NPA has an isoelectric point between pH 4.2 and pH 4.6 with a specific binding activity toward alpha-D-mannose, although studies have suggested that the purified lectin may have greater affinity for internal mannosyl residues than for nonreducing terminal units.
Human studies have found NPA to be nearly non-mitogenic, but it has been reported through an in vitro study that mitogenicity of NPA is age-related, with lymphoproliferative response of peripheral blood mononuclear cells (PBMC) in umbilical cord blood has a sevenfold increase than adult blood. NPA has also been found to be mitogenic for PBMC from lambs and not adult sheep.
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