GLYcoDiag
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GLYcoDiag es una empresa de investigación y desarrollo especializada en glicociencias que ofrece servicios y productos para los campos de la salud (biomarcadores, glicoproteínas recombinantes terapéuticas, vacunas), la cosmética (principios activos, diseño y mecanismos de "glicoactivos") y el medio ambiente (biopelículas, aguas residuales).
Desde 2015, GLYcoDiag desarrolla su propia gama de reactivos y kits para usos de investigación:
Lectinas naturales y recombinantes
Neoglicoproteínas y neoglicoclusters
Geles LEctPROFILE®, geles CarbPROFILE Kits LEctPROFILE® (kits basados en lectinas destinados al cribado / comparación / detección de ligandos) Página web: www.glycodiag.com
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Musa acuminata Lectin (BanLec)
Musa acuminata lectin (BanLec) is isolated from banana pulp and purified by affinity column chromatography on a Mannose-Sepharose 6B-CL gel. This Jacalin-type lectin is a dimeric lectin composed of two identical subunits of 15 kDa.
BanLec shows affinity towards:
- terminal α-D-mannosyl/glycosyl units
- internal α-1,3-mannosyl/glucosyl units
- terminal β-1,3-glucosyl units.
The recognition of both internal 3-O-mannosyl/glucosyl residues and the reducing terminal 3-O-mannosyl/glucosyl unit of oligosaccharides make BanLec unique in its carbohydrate binding properties.
BanLec agglutinates rabbit erythrocytes. Moreover, BanLec has been demonstrated to be a powerful murine Tcell mitogen and also has been shown to stimulate human T-cell profileration.
BanLec is known to be a potential immunomodulatory molecule and has demonstrated to inhibit HIV-1 by binding directly to gp120 (HIV-1 envelope protein) and being able to block HIV-1 cellular entry. It has a potential anti-viral microbicide that could be used to prevent sexual transmission of HIV-1. BanLec has an activity dependent on metal ions (Ca2+, Mn2+, Mg2+) and exhibits a strong mitogenic activity towards murine T-cells. It is a stable glycoprotein that agglutinates rabbit erythrocytes.
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