GLYcoDiag
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GLYcoDiag es una empresa de investigación y desarrollo especializada en glicociencias que ofrece servicios y productos para los campos de la salud (biomarcadores, glicoproteínas recombinantes terapéuticas, vacunas), la cosmética (principios activos, diseño y mecanismos de "glicoactivos") y el medio ambiente (biopelículas, aguas residuales).
Desde 2015, GLYcoDiag desarrolla su propia gama de reactivos y kits para usos de investigación:
Lectinas naturales y recombinantes
Neoglicoproteínas y neoglicoclusters
Geles LEctPROFILE®, geles CarbPROFILE Kits LEctPROFILE® (kits basados en lectinas destinados al cribado / comparación / detección de ligandos) Página web: www.glycodiag.com
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Astragalus membranaceus Lectin (AML)
Astragalus membranaceus, in Chinese, is a plant with flowers of the family of Fabaceae. It is one of the 50 fundamental herbs used in traditional Chinese medicine.
The chemical constituents of the roots (Radix Astragali) include polysaccharides and triterpenoids (such as astragalosides), as well as isoflavones (including kumatakenin, calycosin and formononetin) and their glycosides and malonates.
Isolated from the roots of the Chinese herb Astragalus membranaceus (Fisch.) Bunge, lectin Astragalus membranaceus (AML) is a monomeric protein with a molecular weight of 31.5 kDa containing 10.7% neutral sugars. AML is best inhibited by D-galactose and its derivatives, with a marked preference for o-nitrophenyl-D-galactopyranoside. This lectin is stable in the pH range of 5.0 to 12.0 and at temperatures up to 55°C for 30 minutes. AML inhibits the proliferation of the HeLa and K562 cell lines, indicating a high potential for anti-tumor activity.
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