![LCP](https://www.clinisciences.com/es/upload/thumbs/bandeau3-hkexqk5q-8FJVJjsN-1ce4ba.png)
LCP
Lipidic Cubic Phase (LCP) Products
Crystallization is usually the bottleneck in membrane protein work.
Temperature, salt and detergent concentrations all affect the crystallization
process. Determining the conditions necessary to crystallize
one protein provides very little insight into the conditions needed to
crystallize another. The process is truly more of an art than a science.
Lipidic Cubic Phase (LCP) promises to remove the crystallization
bottleneck. The Anatrace LCP product range includes both monoolein
and monopalmitolein products. Both molecules have the ability in
aqueous solution to self-assemble into a lattice structure. Conceptually,
the lattice is comprised of a quasi lipid phase and channels. While
the quasi lipid component suspends proteins and is chemically similar
to a lipid bi-layer, the channels allow water-soluble material to pass
through the lattice.
The multi-layered lattice structure itself acts as a trap and constrains
any membrane protein which slips or diffuses into it. Inside of the
lattice, proteins can diffuse laterally through the structure and this
process helps separate out water-soluble impurities which affect
crystallization. Once proteins are suspended in the lattice, the aqueous
solution is allowed to evaporate, and the trapped proteins eventually
reach the needed supersaturated state. At this point, the lattice
structure contributes one last important service. The LCP limits protein
movement and creates the order needed for crystal growth to begin.
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