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SARS-CoV-2 - Spike protein - Primary antibodies
The SARS-CoV-2 virus, the cause of the current Covid-19 pendemia, can infect human respiratory epithelial cells through an interaction with the human ACE2 receptor or angiotensin converting enzyme receptor 2. SARS-CoV-2 has on its surface a protein called Spike or S protein. This type I transmembrane protein is present on the viral envelope in the form of a homotrimer. Each monomer consists of 2 subunits, S1 and S2. The S1 subunit contains a receptor binding domain (RBD) which binds to the ACE2 receptor on the host membrane. The S2 sub-unit is activated by the bond between S1 and the ACE2 receptor and contains the elements necessary for membrane fusion. The S protein thus plays an important role in the infection of SARS-CoV-2 as well as in the induction of neutralizing antibody and T cell responses and in protective immunity.
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RUOCE / IVD
- Unconjugated 99
- virus 87
- human 22
- mouse 2
- Primary antibody
- rabbit 38
- human 18
- goat 12
- mouse 4
- WB 57
- ELISA 49
- IF 16
- IP 15
- IHC 2
- ICC 1
- Polyclonal 47
- 1H11 3
- 27B12 3
- 27C2 3
- 28H3 3
- 30C5 3
- 36A7 3
- 38G5 3
- 49F9 3
- 58F8 3
- 60E10 3
- 6G7 3
- 71D2 3
- 72A5 3
- 79C3 3
- 8E5 3
- S4245RM 3
- 4H8 2
- 6C7 2
- Monoclonal 2
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