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> Acalabrutinib-d4 [2699608-18-7]

Acalabrutinib-d4 [2699608-18-7]

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Acalabrutinib-d4 is a deuterium labeled Acalabrutinib. Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor[1]. Acalabrutinib-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Acalabrutinib-d<sub>4</sub> Estructura química

Acalabrutinib-d4 Estructura química

No. CAS : 2699608-18-7

This product is a controlled substance and not for sale in your territory.

Based on 1 publication(s) in Google Scholar

Other Forms of Acalabrutinib-d4:

  • Acalabrutinib In-stock
  • Acalabrutinib-d3 Obtener un presupuesto
Descripciòn

Acalabrutinib-d4 is a deuterium labeled Acalabrutinib. Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor[1]. Acalabrutinib-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Peso molecular

469.53

Fòrmula

C26H19D4N7O2
No. CAS

2699608-18-7
Unlabeled CAS

1420477-60-6
Appearance

Solid

Color

Light yellow to light brown

SMILES

O=C(NC1=NC([2H])=C([2H])C([2H])=C1[2H])C2=CC=C(C3=C4C(N)=NC=CN4C([C@H]5N(C(C#CC)=O)CCC5)=N3)C=C2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 250 mg/mL (532.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 250 mg/mL (532.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1298 mL 10.6489 mL 21.2979 mL
5 mM 0.4260 mL 2.1298 mL 4.2596 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación

Purity: 99.50%

COA (252 KB) LCMS (100 KB)

Instrucciones de manejo (2659 KB)
Referencias

  • [1]. Wu J, et al. Acalabrutinib (ACP-196): a selective second-generation BTK inhibitor. J Hematol Oncol. 2016 Mar 9;9:21  [Content Brief]

  • [1]. Wu J, et al. Acalabrutinib (ACP-196): a selective second-generation BTK inhibitor. J Hematol Oncol. 2016 Mar 9;9:21

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 2.1298 mL 10.6489 mL 21.2979 mL 53.2447 mL
5 mM 0.4260 mL 2.1298 mL 4.2596 mL 10.6489 mL
10 mM 0.2130 mL 1.0649 mL 2.1298 mL 5.3245 mL
15 mM 0.1420 mL 0.7099 mL 1.4199 mL 3.5496 mL
20 mM 0.1065 mL 0.5324 mL 1.0649 mL 2.6622 mL
25 mM 0.0852 mL 0.4260 mL 0.8519 mL 2.1298 mL
30 mM 0.0710 mL 0.3550 mL 0.7099 mL 1.7748 mL
40 mM 0.0532 mL 0.2662 mL 0.5324 mL 1.3311 mL
50 mM 0.0426 mL 0.2130 mL 0.4260 mL 1.0649 mL
60 mM 0.0355 mL 0.1775 mL 0.3550 mL 0.8874 mL
80 mM 0.0266 mL 0.1331 mL 0.2662 mL 0.6656 mL
100 mM 0.0213 mL 0.1065 mL 0.2130 mL 0.5324 mL
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Acalabrutinib-d4 Related Classifications

  • Cancer
  • Cancer Targeted Therapy
  • Protein Tyrosine Kinase/RTK
  • Btk
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acalabrutinib-d42699608-18-7ACP-196-d4BtkBruton tyrosine kinaseorallyirreversibletyrosinephosphorylationERKIKBAKTCLLCys481on-targetchroniclymphocyticleukemiaPLCγ2Inhibitorinhibitorinhibit