Anti-CD36 antibody (Clone: 5-271) {APC}

Clonality:	Monoclonal
Clone ID:	5-271
Conjugation:	APC
Isotype:	IgG2ak
Formulation:	PBS with 0.05% Proclin300, 1% BSA
Storage Instruction:	Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.

Gene Symbol:	CD36
Gene ID:	948
Uniprot ID:	CD36_HUMAN

Post Translational Modifications	N-glycosylated and O-glycosylated with a ratio of 2:1. Palmitoylated by ZDHHC5. Palmitoylation is required for proper localization at the plasma membrane. Ubiquitinated at Lys-469 and Lys-472. Ubiquitination is induced by fatty acids such as oleic acid and leads to degradation by the proteasome. Ubiquitination and degradation are inhibited by insulin which blocks the effect of fatty acids.
Function	Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption. Mechanistically, binding of fatty acids activates downstream kinase LYN, which phosphorylates the palmitoyltransferase ZDHHC5 and inactivates it, resulting in the subsequent depalmitoylation of CD36 and caveolar endocytosis. In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway. Involved in oral fat perception and preferences. Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions. In taste receptor cells, mediates the induction of an increase in intracellular calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract. Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis. Receptor for thrombospondins, THBS1 and THBS2, mediating their antiangiogenic effects. Involved in inducing apoptosis in podocytes in response to elevated free fatty acids, acting together with THBS1. As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome. Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. (Microbial infection) Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and the internalization of particles independently of TLR signaling.
Protein Name	Platelet Glycoprotein 4 Fatty Acid Translocase Fat Glycoprotein Iiib Gpiiib Leukocyte Differentiation Antigen Cd36 Pas Iv Pas-4 Platelet Collagen Receptor Platelet Glycoprotein Iv Gpiv Thrombospondin Receptor Cd Antigen Cd36
Database Links	Reactome: R-HSA-114608 Reactome: R-HSA-1236973 Reactome: R-HSA-1236974 Reactome: R-HSA-166058 Reactome: R-HSA-168188 Reactome: R-HSA-1989781 Reactome: R-HSA-3000471 Reactome: R-HSA-381340 Reactome: R-HSA-434313 Reactome: R-HSA-5602498 Reactome: R-HSA-5603041 Reactome: R-HSA-5686938 Reactome: R-HSA-6785807 Reactome: R-HSA-6798695
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Membrane Raft Golgi Apparatus Apical Cell Membrane Upon Ligand-Binding Internalized Through Dynamin-Dependent Endocytosis
Alternative Antibody Names	Anti-Platelet Glycoprotein 4 antibody Anti-Fatty Acid Translocase antibody Anti-Fat antibody Anti-Glycoprotein Iiib antibody Anti-Gpiiib antibody Anti-Leukocyte Differentiation Antigen Cd36 antibody Anti-Pas Iv antibody Anti-Pas-4 antibody Anti-Platelet Collagen Receptor antibody Anti-Platelet Glycoprotein Iv antibody Anti-Gpiv antibody Anti-Thrombospondin Receptor antibody Anti-Cd Antigen Cd36 antibody Anti-CD36 antibody Anti-GP3B antibody Anti-GP4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance