General Info
Host: | Rabbit |
Applications: | ELISA/IP/WB |
Reactivity: | Chicken/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-PDE4D7 is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | FITC |
Isotype: | IgG |
Purification: | Affinity Purified |
Concentration: | 0.2 µg/µl |
Dilution Range: | WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:150 |
Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Information
Gene Symbol: | Pde4d |
Gene ID: | 238871 |
Uniprot ID: | PDE4D_MOUSE |
Specificity: | Does not crossDoes not cross react with other PDE family members including PDE4A, PDE4B or PDE4C. |
Immunogen: | Synthetic peptide corresponding to unique amino acid sequence on PDE4D7 variant. |
Description
Tissue Specificity | Expressed in brain (at protein level). Isoform 7 is detected in heart, brain, lung, kidney and testis. |
Post Translational Modifications | Sumoylation of long isoforms by PIAS4 augments their activation by PKA phosphorylation and represses their inhibition by ERK phosphorylation. |
Function | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. |
Protein Name | Camp-Specific 3' -5'-Cyclic Phosphodiesterase 4d Dpde3 |
Database Links | Reactome: R-MMU-180024 Reactome: -MMU-418555 |
Cellular Localisation | Cytoplasm Membrane Cytoskeleton Microtubule Organizing Center Centrosome Apical Cell Membrane Colocalized With Shank2 To The Apical Membrane Of Colonic Crypt Cells Found In The Soluble Fraction Associated With Membranes And Associated With The Cytoskeleton And The Centrosome |
Alternative Antibody Names | Anti-Camp-Specific 3' -5'-Cyclic Phosphodiesterase 4d antibody Anti-Dpde3 antibody Anti-Pde4d antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance