Apolipoprotein E, Human (Apo E)

Referencia A2299-73-50ug

embalaje : 50ug

Marca : US Biological

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A2299-73 Apolipoprotein E, Human (Apo E) discontinued

Clone Type
Polyclonal
Grade
Highly Purified
Applications
E
Shipping Temp
Dry Ice
Storage Temp
-70°C

The apolipoproteins are family of amphipathic lipoproteins that plays a crucial role in lipid metabolism. In particular, apolipoprotein E (apo E) is a major component of high density lipoproteins (HDL) chylomicrons and very low-density lipoprotein (VLDL), which functions to remove excess cholesterol. Apo E mediates lipid metabolism and cholesterol homeostasis by binding to several hepatic lipoprotein receptors, such as low density lipoprotein receptor (LDLR) and the LDLR-related protein (1). Apo E deficiency is linked to hyperlipoproteinemia type III; a genetic disorder characterized by elevated plasma cholesterol and triglyceride levels and accelerated coronary artery disease (2). Three major isoforms of Apo E (E2, E3, E4) has been identified, with E3 being the most common in human. E4 presence has been associated to increase probability of developing late-onset form of Alzheimer disease (3).||Applications: |Suitable for use in ELISA. Other applications not tested.||Recommended Dilutions:|Optimal dilutions to be determined by the researcher.||Storage and Stability:|Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Applications
Source: Human plasma, VLDL|Purity: ≥98% (SDS-PAGE)|Concentration: ~0.5mg/ml|Form: Supplied as a liquid in 0.01M ammonium bicarbonate, pH 8.0||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Form
Supplied as a liquid in 0.01M ammonium bicarbonate, pH 8.0
Purity
≥98% (SDS-PAGE)