ARC (Nucleolar Protein 3, Apoptosis repressor with CARD, Muscle-enriched Cytoplasmic Protein, Myp, Nucleolar Protein of 30kD, Nop30, NOL3, ARC, NOP)

This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. Arc has been shown to localize to the cytoskeleton of neuronal cells and appears to colocalize with F-Actin, although it may associate with an Actin-associated protein rather than directly with F-Actin. It has been shown that cocaine-stimulated neuronal activity results in increased Arc mRNA levels in striatum.||Applications: |Suitable for use in ELISA and Immunohistochemistry. Other applications not tested.||Recommended Dilution:|ELISA: 1:2000-1:5000|Immunohistochemistry: 1:50-1:200|Optimal dilutions to be determined by the researcher.||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.