Clindamycin (hydrochloride) [21462-39-5]
Referencia HY-B0408A-5g
embalaje : 5g
Marca : MedChemExpress
Clindamycin (hydrochloride) is a semisynthetic lincosamide antibiotic, which inhibits protein synthesis by acting on the 50S ribosomal.
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Clindamycin hydrochloride Estructura química
No. CAS : 21462-39-5
This product is a controlled substance and not for sale in your territory.
Based on 6 publication(s) in Google Scholar
Other Forms of Clindamycin hydrochloride:
- Clindamycin phosphate In-stock
- Clindamycin palmitate hydrochloride In-stock
- Clindamycin In-stock
- Clindamycin phosphate hydrochloride Obtener un presupuesto
- Clindamycin hydrochloride monohydrate Obtener un presupuesto
Descripciòn |
Clindamycin (hydrochloride) is a semisynthetic lincosamide antibiotic, which inhibits protein synthesis by acting on the 50S ribosomal. |
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In Vitro |
Clindamycin is a classical inhibitor of bacterial protein synthesis, by binding to the 23S ribosomal RNA of the 50S ribosomal subunit[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
Clindamycin hydrochloride results in fast absorption after oral administration in dogs, with a mean absorption time (MAT) of 0.87 hour, and bioavailability is 72.55%. Clindamycin hydrochloride results in total clearance (CL) of Clindamycin after both IV and oral administration (0.503 vs. 0.458 L/h/kg) in dogs. Clindamycin hydrochloride results in volume of distribution at steady-state (IV) at 2.48 L/kg, indicating a wide distribution of clindamycin in body fluids and tissues. Clindamycin serum concentrations after IV and oral administration remain above 0.5 μg/mL approximately for 10 hours[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Ensayo clínico |
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Peso molecular |
461.44 |
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Fòrmula |
C18H34Cl2N2O5S |
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No. CAS |
21462-39-5 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
C[C@H](Cl)[C@@]([C@@]([C@@H]([C@H](O)[C@H]1O)O)(00)O[C@@H]1SC)(00)NC([C@@H]2C[C@@H](CCC)CN2C)=O.Cl |
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Envío | Room temperature in continental US; may vary elsewhere. |
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Almacenamiento |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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Solvente y solubilidad |
In Vitro:
DMSO : ≥ 100 mg/mL (216.71 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O : ≥ 100 mg/mL (216.71 mM) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Pureza y Documentación |
Purity: ≥98.0% |
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Referencias |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO / H2O | 1 mM | 2.1671 mL | 10.8356 mL | 21.6713 mL | 54.1782 mL |
5 mM | 0.4334 mL | 2.1671 mL | 4.3343 mL | 10.8356 mL | |
10 mM | 0.2167 mL | 1.0836 mL | 2.1671 mL | 5.4178 mL | |
15 mM | 0.1445 mL | 0.7224 mL | 1.4448 mL | 3.6119 mL | |
20 mM | 0.1084 mL | 0.5418 mL | 1.0836 mL | 2.7089 mL | |
25 mM | 0.0867 mL | 0.4334 mL | 0.8669 mL | 2.1671 mL | |
30 mM | 0.0722 mL | 0.3612 mL | 0.7224 mL | 1.8059 mL | |
40 mM | 0.0542 mL | 0.2709 mL | 0.5418 mL | 1.3545 mL | |
50 mM | 0.0433 mL | 0.2167 mL | 0.4334 mL | 1.0836 mL | |
60 mM | 0.0361 mL | 0.1806 mL | 0.3612 mL | 0.9030 mL | |
80 mM | 0.0271 mL | 0.1354 mL | 0.2709 mL | 0.6772 mL | |
100 mM | 0.0217 mL | 0.1084 mL | 0.2167 mL | 0.5418 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.