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CysOx2

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CysOx2 is a reaction-based fluorogenic probe for sulfenic acid (Ex/Em: 394/535 nm). CysOx2 can be used for detecting protein cysteine oxidation in living cells.

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CysOx2 Estructura química

CysOx2 Estructura química

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Descripciòn

CysOx2 is a reaction-based fluorogenic probe for sulfenic acid (Ex/Em: 394/535 nm). CysOx2 can be used for detecting protein cysteine oxidation in living cells[1].

IC50 & Target

Sulfenic acid[1]
In Vitro

CysOx2 (1 mM; 1 h) reacts with H2O2 and produces fluorescence in 50 mM HEPES pH 7.4[1].
CysOx2 is cell permeable[1].
CysOx2 (50 μM; 1 h) shows fluorescence signal in epitope-tagged wild-type EGFR expression HeLa cells, the signal is absent in C797S EGFR expression HeLa cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CysOx2 Related Antibodies
Peso molecular

305.32

Fòrmula

C15H12FNO3S
SMILES

O=C1CS(=O)(C2=CC(F)=C(C3=CC=CC1=C32)N4CCC4)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias

  • [1]. Ferreira RB, et al. Reaction-based fluorogenic probes for detecting protein cysteine oxidation in living cells. Nat Commun. 2022 Sep 21;13(1):5522.  [Content Brief]

  • [1]. Ferreira RB, et al. Reaction-based fluorogenic probes for detecting protein cysteine oxidation in living cells. Nat Commun. 2022 Sep 21;13(1):5522.

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CysOx2 Related Classifications

  • Others
  • Fluorescent Dye

  • Calculadora de molaridad

  • Calculadora de dilución

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CysOx2CysOx 2CysOx-2Fluorescent Dyesulfenic acidliving cellcysteine oxidationfluorogenic probeInhibitorinhibitorinhibit