Human VGF (VGF Nerve Growth Factor Inducible) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	VGF
Gene ID:	7425
Uniprot ID:	VGF_HUMAN
Sample Type:	serum, plasma or other biological fluids.

Tissue Specificity	Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells.
Post Translational Modifications	Multiple peptides are derived from VGF, with activities in synaptic plasticity, antidepression, penile erection, autonomic activation, and increases in energy expenditure.
Function	Neurosecretory protein VGF: Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner. VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain. Neuroendocrine regulatory peptide-1: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Suppresses presynaptic glutamatergic neurons connected to vasopressin neurons. Neuroendocrine regulatory peptide-2: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Activates GABAergic interneurons which are inhibitory neurons of the nervous system and thereby suppresses presynaptic glutamatergic neurons. Stimulates also feeding behavior in an orexin-dependent manner in the hypothalamus. Functions as a positive regulator for the activation of orexin neurons resulting in elevated gastric acid secretion and gastric emptying. VGF-derived peptide TLQP-21: Secreted multifunctional neuropeptide that binds to different cell receptors and thereby plays multiple physiological roles including modulation of energy expenditure, pain, response to stress, gastric regulation, glucose homeostasis as well as lipolysis. Activates the G-protein-coupled receptor C3AR1 via a folding-upon-binding mechanism leading to enhanced lipolysis in adipocytes. Interacts with C1QBP receptor in macrophages and microglia causing increased levels of intracellular calcium and hypersensitivity. VGF-derived peptide TLQP-62: Plays a role in the regulation of memory formation and depression-related behaviors potentially by influencing synaptic plasticity and neurogenesis. Induces acute and transient activation of the NTRK2/TRKB receptor and subsequent CREB phosphorylation. Induces also insulin secretion in insulinoma cells by increasing intracellular calcium mobilization. Antimicrobial peptide VGF554-577: Has bactericidal activity against M. luteus, and antifungal activity against P. Pastoris.
Protein Name	Neurosecretory Protein Vgf Cleaved Into - Neuroendocrine Regulatory Peptide-1 Nerp-1 - Neuroendocrine Regulatory Peptide-2 Nerp-2 - Vgf-Derived Peptide Tlqp-21 - Vgf-Derived Peptide Tlqp-62 - Antimicrobial Peptide Vgf554-577
Database Links	Reactome: R-HSA-381426 Reactome: R-HSA-8957275 Reactome: R-HSA-9031628
Cellular Localisation	Neurosecretory Protein Vgf: Secreted Cytoplasmic Vesicle Secretory Vesicle Stored In Secretory Vesicles And Then Secreted Nerp Peptides Colocalize With Vasopressin In The Storage Granules Of Hypothalamus
Alternative ELISA Names	Neurosecretory Protein Vgf Cleaved Into - Neuroendocrine Regulatory Peptide-1 ELISA kit Nerp-1 - Neuroendocrine Regulatory Peptide-2 ELISA kit Nerp-2 - Vgf-Derived Peptide Tlqp-21 - Vgf-Derived Peptide Tlqp-62 - Antimicrobial Peptide Vgf554-577 ELISA kit VGF ELISA kit
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Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance