Levamisole (hydrochloride) [16595-80-5]
Referencia HY-13666-10g
embalaje : 10g
Marca : MedChemExpress
Levamisole ((-)-Tetramisole) hydrochloride is an anthelmintic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives. Levamisole hydrochloride has antiviral effects against HSV.
Para uso exclusivo en investigación. No vendemos a pacientes.
Levamisole hydrochloride Estructura química
No. CAS : 16595-80-5
This product is a controlled substance and not for sale in your territory.
Based on 4 publication(s) in Google Scholar
Other Forms of Levamisole hydrochloride:
- Levamisole In-stock
- Levamisole-d5 hydrochloride Obtener un presupuesto
Ver todos los productos específicos de isoformas Parasite:
Ver todos los productos específicos de isoformas HSV:
Descripciòn |
Levamisole ((-)-Tetramisole) hydrochloride is an anthelmintic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives. Levamisole hydrochloride has antiviral effects against HSV. |
||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IC50 & Target[1][2][3] |
|
||||||||||||
In Vitro |
Levamisole suppresses the production of white blood cells, resulting in neutropenia and agranulocytosis. With the increasing use of levamisole as an adulterant, a number of these complications have been reported among cocaine users [1] [2]. Levamisole reversibly and noncompetitively inhibits most isoforms of alkaline phosphatase (e.g., human liver, bone, kidney, and spleen) except the intestinal and placental isoform [3]. It is thus used as an inhibitor along with substrate to reduce background alkaline phosphatase activity in biomedical assays involving detection signal amplification by intestinal alkaline phosphatase, for example in in situ hybridization or Western blot protocols. It is used to immobilize the nematode C. elegans on glass slides for imaging. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
||||||||||||
Ensayo clínico |
|
||||||||||||
Peso molecular |
240.75 |
||||||||||||
Fòrmula |
C11H13ClN2S |
||||||||||||
No. CAS |
16595-80-5 |
||||||||||||
Appearance |
Solid |
||||||||||||
Color |
White to off-white |
||||||||||||
SMILES |
22Cl.C12=N[C@@H](C3=CC=CC=C3)CN1CCS2 |
||||||||||||
Envío | Room temperature in continental US; may vary elsewhere. |
||||||||||||
Almacenamiento |
4°C, sealed storage, away from moisture *In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture) |
||||||||||||
Solvente y solubilidad |
In Vitro:
H2O : 50 mg/mL (207.68 mM; Need ultrasonic) DMSO : 15.5 mg/mL (64.38 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Ethanol : 12.5 mg/mL (51.92 mM; Need ultrasonic) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
|
||||||||||||
Pureza y Documentación |
Purity: 99.87% |
||||||||||||
Referencias |
|
Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
---|
Ethanol / DMSO / H2O | 1 mM | 4.1537 mL | 20.7684 mL | 41.5369 mL | 103.8422 mL |
5 mM | 0.8307 mL | 4.1537 mL | 8.3074 mL | 20.7684 mL | |
10 mM | 0.4154 mL | 2.0768 mL | 4.1537 mL | 10.3842 mL | |
15 mM | 0.2769 mL | 1.3846 mL | 2.7691 mL | 6.9228 mL | |
20 mM | 0.2077 mL | 1.0384 mL | 2.0768 mL | 5.1921 mL | |
25 mM | 0.1661 mL | 0.8307 mL | 1.6615 mL | 4.1537 mL | |
30 mM | 0.1385 mL | 0.6923 mL | 1.3846 mL | 3.4614 mL | |
40 mM | 0.1038 mL | 0.5192 mL | 1.0384 mL | 2.5961 mL | |
50 mM | 0.0831 mL | 0.4154 mL | 0.8307 mL | 2.0768 mL | |
DMSO / H2O | 60 mM | 0.0692 mL | 0.3461 mL | 0.6923 mL | 1.7307 mL |
H2O | 80 mM | 0.0519 mL | 0.2596 mL | 0.5192 mL | 1.2980 mL |
100 mM | 0.0415 mL | 0.2077 mL | 0.4154 mL | 1.0384 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Levamisole hydrochloride Related Classifications
- Anti-infection
- Parasite HSV