Mitotane
Referencia M3425-500mg
embalaje : 500mg
Marca : AbMole Bioscience
Contact local distributor :
Teléfono : +1 850 650 7790
All AbMole products are for research use only, cannot be used for human consumption.
2,4′-DDD; o,p'-DDD
Quality Control & Documentation
Biological Activity
Mitotane is an isomer of DDD and a derivative of DDT that induces CYP3A4 gene expression through steroid and exogenous receptor (SXR) activation, and has anticancer activity, and may be used in studies related to adrenocortical carcinoma.
Chemical Information
| Molecular Weight | 320.04 |
| Formula | C14H10Cl4 |
| CAS Number | 53-19-0 |
| Form | Solid |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage | Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
References
[1] Malik Salman Haider, et al. The Challenging Pharmacokinetics of Mitotane: An Old Drug in Need of New Packaging
[2] Rebecca V Steenaard, et al. How close are we to personalized mitotane dosing in the treatment of adrenocortical carcinoma? State of the art and future perspectives
[3] Claudia Rita Corso, et al. Pharmacological profile and effects of mitotane in adrenocortical carcinoma
[4] U Waszut, et al. Understanding mitotane mode of action
[5] Stefanie Hahner, et al. Mitotane for adrenocortical carcinoma treatment