Mouse Sirt1 activation kit by CRISPRa
Referencia GA211352
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Mouse Sirt1 activation kit by CRISPRa
SKU
GA211352
Sirt1 CRISPRa kit - CRISPR gene activation of mouse sirtuin 1
2 Weeks*
| Product Data | |
| Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
|---|---|
| Target Symbol | Sirt1 |
| Locus ID | 93759 |
| Components | GA211352G1, Sirt1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211352G2, Sirt1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211352G3, Sirt1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
| Reference Data | |
| RefSeq | NM_001159589, NM_001159590, NM_019812 |
| UniProt ID | Q923E4 |
| Synonyms | AA673258; Sir2; Sir2a; Sir2alpha; SIR2L1 |
| Summary | This gene encodes a member of the sirtuin family of proteins, characterized by their deacetylase activity and proposed role in longevity. The encoded protein regulates gene expression in a wide range of cell and tissue types through its NAD+-dependent deacetylation of histones, transcription factors and transcriptional coactivators. Brain-specific overexpression of this gene has been shown to result in increased median lifespan. Viability of homozygous knockout mice for this gene varies with strain background. Homozygous knockout mice of strains that do not exhibit embryonic lethality are sterile and have a reduced lifespan. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] |
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| SDS |
| SKU | Description | Size | ||
|---|---|---|---|---|
| KN515801 | Sirt1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. | 1 kit | | |
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.