NPPB (B-type Natriuretic Peptide, Brain Natriuretic Peptide, BNP, Gamma-brain Natriuretic Peptide)

B-type natriuretic peptide (BNP) is a cardiac neurohormone specifically secreted from the ventricles in response to volume expansion and pressure overload (1). The actions of BNP include natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. It is also found to help restore the body's salt and water balance and improve heart function (2). BNP is co-secreted along with a biologically inactive N-terminal fragment (NT-proBNP). Circulating BNP and NT-proBNP provide important information on cardiac dysfunction, hypervolemia, and risk in patients with severe impairment of kidney function (3).||Applications: |Suitable for use in Western Blot. Other applications not tested.||Recommended Dilution:|Western Blot: 1:500-1:2000|Optimal dilutions to be determined by the researcher.||Storage and Stability: |May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.