PD-1/PD-L1-IN 3 (TFA)
Referencia HY-103048A-1mg
embalaje : 1mg
Marca : MedChemExpress
Contact local distributor :
Teléfono : +1 850 650 7790
PD-1/PD-L1-IN 3 TFA, a macrocyclic peptide, is a potent and selective inhibitor of the PD-1/PD-L1 and CD80/PD-L1 interactions extracted from patent WO2014151634A1, compound No.1. PD-1/PD-L1-IN 3 TFA interferes with PD-L1 binding to PD-1 and CD80 by binding to PD-L1, with IC50s of 5.60 nM and 7.04 nM, respectively. PD-1/PD-L1-IN 3 TFA can be used for the research of various diseases, including cancer and infectious diseases.
Para uso exclusivo en investigación. No vendemos a pacientes.
PD-1/PD-L1-IN 3 TFA Estructura química
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Other Forms of PD-1/PD-L1-IN 3 TFA:
- PD-1/PD-L1-IN 3 Obtener un presupuesto
| Descripciòn |
PD-1/PD-L1-IN 3 TFA, a macrocyclic peptide, is a potent and selective inhibitor of the PD-1/PD-L1 and CD80/PD-L1 interactions extracted from patent WO2014151634A1, compound No.1. PD-1/PD-L1-IN 3 TFA interferes with PD-L1 binding to PD-1 and CD80 by binding to PD-L1, with IC50s of 5.60 nM and 7.04 nM, respectively. PD-1/PD-L1-IN 3 TFA can be used for the research of various diseases, including cancer and infectious diseases[1]. |
IC50 & Target |
IC50: 5.60 nM (PD-1/PD-L1); 7.04 nM (CD80/PD-L1)[1] |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| In Vitro |
PD-1/PD-L1-IN 3 (0.1 nM-10 μM) inhibits the binding of PD-1 and CD80 to PD-L1, with IC50s of 5.60 nM and 7.04 nM[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
||||||||||||
| Peso molecular |
1966.19 |
||||||||||||
| Fòrmula |
C91H127F3N24O20S |
||||||||||||
| Appearance |
Solid |
||||||||||||
| Color |
White to off-white |
||||||||||||
| Sequence Shortening |
Maa-FANPHL-Sar-WSW-Nle-Nle-RCG (Disulfide bridge: Maa1-Cys15) |
||||||||||||
| SMILES |
OC(C(F)(F)F)=O.O=C(N([C@H](C(N([C@H](C(N[C@H](C(N[C@](CSCC(N[C@H](C(N([C@H](C(N[C@H](C(N1CCC[C@]1(C(N[C@](15)(C(N[C@H](C(N(CC(N[C@H](C(N[C@H](C2=O)CO)=O)CC3=CNC4=CC=CC=C34)=O)C)=O)CC(C)C)=O)CC5=CN=CN5)=O)15)=O)CC(N)=O)=O)C)C)=O)CC6=CC=CC=C6)=O)(15)C(NCC(N)=O)=O)=O)CCCNC(N)=N)=O)CCCC)C)=O)CCCC)C)[C@](N2)(15)CC7=CNC8=CC=CC=C78 |
||||||||||||
| Envío | Room temperature in continental US; may vary elsewhere. |
||||||||||||
| Almacenamiento |
Sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
||||||||||||
| Solvente y solubilidad |
In Vitro:
H2O : 50 mg/mL (25.43 mM; Need ultrasonic) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
|
||||||||||||
| Pureza y Documentación | |||||||||||||
| Referencias |
|
Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|
| H2O | 1 mM | 0.5086 mL | 2.5430 mL | 5.0860 mL | 12.7149 mL |
| 5 mM | 0.1017 mL | 0.5086 mL | 1.0172 mL | 2.5430 mL | |
| 10 mM | 0.0509 mL | 0.2543 mL | 0.5086 mL | 1.2715 mL | |
| 15 mM | 0.0339 mL | 0.1695 mL | 0.3391 mL | 0.8477 mL | |
| 20 mM | 0.0254 mL | 0.1271 mL | 0.2543 mL | 0.6357 mL | |
| 25 mM | 0.0203 mL | 0.1017 mL | 0.2034 mL | 0.5086 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
PD-1/PD-L1-IN 3 TFA Related Classifications
- Immunology/Inflammation
- PD-1/PD-L1