Rat NRG1 (Neuregulin 1) Sandwich ELISA Kit Ready-To-Use

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	Nrg1Uniprot ID=NRG1_RAT"
Immunogen Region:	Ready-To-Use
Sample Type:	serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Tissue Specificity	Widely expressed. Most tissues contain isoform alpha2A and isoform alpha2B. Isoform Alpha2 and isoform beta2 are the predominant forms in mesenchymal and non-neuronal organs. Isoform Beta1 is enriched in brain and spinal cord, but not in muscle and heart. Isoform Alpha2C is highly expressed in spinal cord, moderately in lung, brain, ovary, and stomach, in low amounts in the kidney, skin and heart and not detected in the liver, spleen, and placenta.
Post Translational Modifications	Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. N- and O-glycosylated. Extensive glycosylation precedes the proteolytic cleavage.
Function	Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells.inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction.stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells.stimulating Schwann cell proliferation.implication in the development of the myocardium such as trabeculation of the developing heart. Binds to ERBB4 and ERBB3. Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1, and ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons.
Protein Name	Pro-Neuregulin-1 - Membrane-Bound Isoform Pro-Nrg1 Cleaved Into - Neuregulin-1 Acetylcholine Receptor-Inducing Activity Aria Glial Growth Factor Heregulin Hrg Neu Differentiation Factor Sensory And Motor Neuron-Derived Factor
Database Links
Cellular Localisation	Pro-Neuregulin-1 Membrane-Bound Isoform: Cell Membrane Single-Pass Type I Membrane Protein Does Not Seem To Be Active Neuregulin-1: Secreted
Alternative ELISA Names	Pro-Neuregulin-1 - Membrane-Bound Isoform ELISA kit Pro-Nrg1 Cleaved Into - Neuregulin-1 ELISA kit Acetylcholine Receptor-Inducing Activity ELISA kit Aria ELISA kit Glial Growth Factor ELISA kit Heregulin ELISA kit Hrg ELISA kit Neu Differentiation Factor ELISA kit Sensory And Motor Neuron-Derived Factor ELISA kit Nrg1 ELISA kit Ndf ELISA kit
output

Information sourced from Uniprot.org

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