TNFSF10 (Human) Recombinant Protein (P01)
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- More Files
- Specifications
Product Description
Human TNFSF10 full-length ORF ( AAH32722, 1 a.a. - 281 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWPKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
56.65
Interspecies Antigen Sequence
Mouse (65)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
- Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
- Gene Info — TNFSF10
Entrez GeneID
8743GeneBank Accession#
BC032722Protein Accession#
AAH32722Gene Name
TNFSF10
Gene Alias
APO2L, Apo-2L, CD253, TL2, TRAIL
Gene Description
tumor necrosis factor (ligand) superfamily, member 10
Omim ID
603598Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. [provided by RefSeq
Other Designations
Apo-2 ligand|TNF-related apoptosis inducing ligand TRAIL|tumor necrosis factor (ligand) family, member 10|tumor necrosis factor apoptosis-inducing ligand splice variant delta
- Interactomes
- Pathways
- Diseases
- Publication Reference
- Up-regulation of miR-146b and Down-regulation of miR-200b Contribute to the Cytotoxic Effect of Histone Deacetylase Inhibitors on ras-Transformed Thyroid Cells.
Borbone E, De Rosa M, Siciliano D, Altucci L, Croce CM, Fusco A.
The Journal of Clinical Endocrinology and Metabolism 2013 Jun; 98(6):E1031.
Application：Func, Proteasome extracts.
- Up-regulation of miR-146b and Down-regulation of miR-200b Contribute to the Cytotoxic Effect of Histone Deacetylase Inhibitors on ras-Transformed Thyroid Cells.