embalaje : 1g
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Animal models
C57BL/6 mice challenged with Clostridium difficile (C. difficile) strain VPI 10463
Dosage form
20 mg/kg
Once daily by oral gavage for 5 days
Applications
Vancomycin treatment of infected mice was associated with improved clinical, diarrhea, and histopathology scores and survival during treatment. However, after discontinuation of the drug, clinical scores and histopathology were worse in treated mice than in untreated infected controls. Decreasing the duration of vancomycin treatment from 5 days to 1 day decreased recurrence and deaths in C. difficile infection.
Note
The technical data provided above is for reference only.
References:
1. Warren CA, van Opstal EJ, Riggins MS, et al. Vancomycin treatment's association with delayed intestinal tissue injury, clostridial overgrowth, and recurrence of Clostridium difficile infection in mice. Antimicrobial Agents and Chemotherapy, 2013, 57(2): 689-696.